解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba7702
更新日期:2020-10-30 00:00:00
abstract::Adjacent neurons in visual cortex have overlapping receptive fields within and across area boundaries, an arrangement theorized to minimize wiring cost. This constraint is traditionally thought to create retinotopic maps of opposing field signs (mirror and nonmirror visual field representations) in adjacent areas, a c...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz8673
更新日期:2020-10-28 00:00:00
abstract::Sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes. Endogenous negative regulators have long been postulated to play an important role in regulating the activity and stability of Na+/K+-ATPase, but characterization o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb8542
更新日期:2020-10-28 00:00:00
abstract::Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7438
更新日期:2020-10-23 00:00:00
abstract::Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of enhancers. Here, we describe an unexpected function of RING1B, which is highly expressed in EwS. ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba3058
更新日期:2020-10-23 00:00:00
abstract::We have positionally cloned the Ym1 gene, with a duplication and a promoter polymorphism, as a major regulator of inflammation. Mice with the RIIIS/J haplotype, with the absence of Ym1 expression, showed reduced susceptibility to mannan-enhanced collagen antibody-induced arthritis and to chronic arthritis induced by i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba9337
更新日期:2020-10-21 00:00:00
abstract::The homotrimeric molecular chaperone Skp of Gram-negative bacteria facilitates the transport of outer membrane proteins across the periplasm. It has been unclear how its activity is modulated during its functional cycle. Here, we report an atomic-resolution characterization of the Escherichia coli Skp monomer-trimer t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5822
更新日期:2020-10-21 00:00:00
abstract::Embodied models suggest that moral judgments are strongly intertwined with first-hand somatic experiences, with some pointing to disgust, and others arguing for a role of pain/harm. Both disgust and pain are unpleasant, arousing experiences, with strong relevance for survival, but with distinctive sensory qualities an...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat4390
更新日期:2020-10-16 00:00:00
abstract::Inputs of nitrogen into terrestrial ecosystems, mainly via the use of ammonium-based fertilizers in agroecosystems, are enormous, but the fate of this nitrogen under elevated atmospheric carbon dioxide (CO2) is not well understood. We have taken advantage of a 15-year free-air CO2 enrichment study to investigate the i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7433
更新日期:2020-10-16 00:00:00
abstract::Adaptation is a fundamental property of sensory systems that can change subjective experiences in the context of recent information. Adaptation has been postulated to arise from recurrent circuit mechanisms or as a consequence of neuronally intrinsic suppression. However, it is unclear whether intrinsic suppression by...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4205
更新日期:2020-10-14 00:00:00
abstract::The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic, a fraction of cGA...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb8941
更新日期:2020-10-14 00:00:00
abstract::Microfluidic devices fabricated via soft lithography have demonstrated compelling applications such as lab-on-a-chip diagnostics, DNA microarrays, and cell-based assays. These technologies could be further developed by directly integrating microfluidics with electronic sensors and curvilinear substrates as well as imp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc9846
更新日期:2020-10-09 00:00:00
abstract::Meta-regressions of around 1000 cases published over the period 1997-2018 suggest that the direction of the relationship between land area and agricultural performance strongly depends on the performance indicator selected. Net value and efficiency indicators show that larger farms tend to be more performant than smal...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb8235
更新日期:2020-10-09 00:00:00
abstract::There have been increasing attempts to reverse habitat degradation through active restoration, but few large-scale successes are reported to guide these efforts. Here, we report outcomes from a unique and very successful seagrass restoration project: Since 1999, over 70 million seeds of a marine angiosperm, eelgrass (...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc6434
更新日期:2020-10-07 00:00:00
abstract::Ontogenetic studies provide clues for understanding important paleobiological aspects of extinct species. When compared to that of modern humans, the adult Neanderthal thorax was shorter, deeper, and wider. This is related to the wide Neanderthal body and is consistent with their hypothetical large requirements for en...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb4377
更新日期:2020-10-07 00:00:00
abstract::Bioengineered three-dimensional (3D) matrices expand our experimental repertoire to study tumor growth and progression in a biologically relevant, yet controlled, manner. Here, we used peptide amphiphiles (PAs) to coassemble with and organize extracellular matrix (ECM) proteins producing tunable 3D models of the tumor...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3298
更新日期:2020-10-02 00:00:00
abstract::Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5351
更新日期:2020-09-30 00:00:00
abstract::Deforestation is the primary driver of carbon losses in tropical forests, but it does not operate alone. Forest fragmentation, a resulting feature of the deforestation process, promotes indirect carbon losses induced by edge effect. This process is not implicitly considered by policies for reducing carbon emissions in...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz8360
更新日期:2020-09-30 00:00:00
abstract::Spatial patterns of gene expression in living organisms orchestrate cell decisions in development, homeostasis, and disease. However, most methods for reconstructing gene patterning in 3D cell culture and artificial tissues are restricted by patterning depth and scale. We introduce a depth- and scale-flexible method t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb9062
更新日期:2020-09-30 00:00:00
abstract::Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0657
更新日期:2020-09-25 00:00:00
abstract::Engineering the thermal conductivity of amorphous materials is highly essential for the thermal management of future electronic devices. Here, we demonstrate the impact of ultrafine nanostructuring on the thermal conductivity reduction of amorphous silicon nitride (a-Si3N4) thin films, in which the thermal transport i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc0075
更新日期:2020-09-25 00:00:00
abstract::Infants' remarkable learning abilities allow them to rapidly acquire many complex skills. It has been suggested that infants achieve this learning by optimally allocating their attention to relevant stimuli in the environment, but the underlying mechanisms remain poorly understood. Here, we modeled infants' looking be...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5053
更新日期:2020-09-23 00:00:00
abstract::Silicic volcanic activity has long been framed as either violently explosive or gently effusive. However, recent observations demonstrate that explosive and effusive behavior can occur simultaneously. Here, we propose that rhyolitic magma feeding subaerial eruptions generally fragments during ascent through the upper ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba7940
更新日期:2020-09-23 00:00:00
abstract::Cellular cross-talk between ubiquitination and other posttranslational modifications contributes to the regulation of numerous processes. One example is ADP-ribosylation of the carboxyl terminus of ubiquitin by the E3 DTX3L/ADP-ribosyltransferase PARP9 heterodimer, but the mechanism remains elusive. Here, we show that...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc0418
更新日期:2020-09-18 00:00:00
abstract::Sleep serves disparate functions, most notably neural repair, metabolite clearance and circuit reorganization. Yet the relative importance remains hotly debated. Here, we create a novel mechanistic framework for understanding and predicting how sleep changes during ontogeny and across phylogeny. We use this theory to ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba0398
更新日期:2020-09-18 00:00:00
abstract::Despite the important roles that horses have played in human history, particularly in the spread of languages and cultures, and correspondingly intensive research on this topic, the origin of domestic horses remains elusive. Several domestication centers have been hypothesized, but most of these have been invalidated ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0030
更新日期:2020-09-16 00:00:00
abstract::Understanding the precise atomic structure of ice surfaces is critical for revealing the mechanisms of physical and chemical phenomena at the surfaces, such as ice growth, melting, and chemical reactions. Nevertheless, no conclusive structure has been established. In this study, noncontact atomic force microscopy was ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7986
更新日期:2020-09-11 00:00:00
abstract::Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment has not been achieved because of the nondegradable risks of photosensitizing drugs and limits of light penetration and instrumentation. Here, we present bioluminescence (BL)-induced proteinaceous PDT (BLiP-PDT), through the ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba3009
更新日期:2020-09-11 00:00:00
abstract::Biodiversity loss is a social and ecological emergency, and calls have been made for the global expansion of protected areas (PAs) to tackle this crisis. It is unclear, however, where best to locate new PAs to protect biodiversity cost-effectively. To answer this question, we conducted a spatial meta-analysis by overl...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc3436
更新日期:2020-09-09 00:00:00
abstract::Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly stiff and fibrous during disease progression, how these physical cues affect myofibroblast differentiation in 3D is poorly understood. Here, we describe a mult...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5069
更新日期:2020-09-09 00:00:00
abstract::Following the onset of the strong 2014-2016 El Niño, a decade-long increase of the basin-wide sea level and heat content in the subtropical southern Indian Ocean (SIO) in 2004-2013 ended with an unprecedented drop, which quickly recovered during the weak 2017-2018 La Niña. Here, we show that the 2014-2016 El Niño cont...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1151
更新日期:2020-09-04 00:00:00
abstract::Passive radiative cooling functions by reflecting the solar spectrum and emitting infrared waves in broadband or selectively. However, cooling enclosed spaces that trap heat by greenhouse effect remains a challenge. We present a Janus emitter (JET) consisting of an Ag-polydimethylsiloxane layer on micropatterned quart...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb1906
更新日期:2020-09-04 00:00:00
abstract::The single-stranded RNA (ssRNA) bacteriophages are among the simplest known viruses with small genomes and exceptionally high mutation rates. The number of ssRNA phage isolates has remained very low, but recent metagenomic studies have uncovered an immense variety of distinct uncultured ssRNA phages. The coat proteins...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc0023
更新日期:2020-09-02 00:00:00
abstract::Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new histones at the promoters of genes. The role of these histone exchange events in transcription remains unclear. In particular, the causal relationship between histone exchange and activator...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0333
更新日期:2020-09-02 00:00:00
abstract::Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb4591
更新日期:2020-08-28 00:00:00
abstract::Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinje neurons undergoin...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba8271
更新日期:2020-08-28 00:00:00
abstract::Deep CO2 emissions characterize many nonvolcanic, seismically active regions worldwide, and the involvement of deep CO2 in the earthquake cycle is now generally recognized. However, no long-time records of such emissions have been published, and the temporal relations between earthquake occurrence and tectonic CO2 rel...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc2938
更新日期:2020-08-26 00:00:00
abstract::Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H2S. Therefore, SQR is assumed to inhibit H2S signaling. We now report that SQR-mediated oxidation o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz5752
更新日期:2020-08-26 00:00:00
abstract::Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7990
更新日期:2020-08-21 00:00:00
abstract::We report a negative resistance, namely, a voltage drop along the opposite direction of a current flow, in the superconducting gap of NbSe2 thin films under the irradiation of surface acoustic waves (SAWs). The amplitude of the negative resistance becomes larger by increasing the SAW power and decreasing temperature. ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1377
更新日期:2020-08-21 00:00:00